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Title: | A genome wide expression profile of non-coding RNAs in human osteosarcoma cells as they acquire resistance to cisplatin |
Authors: | Chowdhury, Rajdeep Chowdhury, Shibasish Mukherjee, Sudeshna |
Keywords: | Biology Genomes RNAs (lncRNAs) |
Issue Date: | Oct-2021 |
Publisher: | Springer |
Abstract: | Recurrence after cisplatin therapy is one of the major hindrances in the management of cancer. This necessitates a deeper understanding of the molecular signatures marking the acquisition of resistance. We therefore modeled the response of osteosarcoma (OS) cells to the first-line chemotherapeutic drug cisplatin. A small population of nondividing cells survived acute cisplatin shock (persisters; OS-P). These cells regained proliferative potential over time re-instating the population again (extended persisters; OS-EP). |
URI: | https://link.springer.com/article/10.1007/s12672-021-00441-6 http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/15370 |
Appears in Collections: | Department of Biological Sciences |
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