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Title: | COVID-19 infection and metabolic comorbidities: Mitigating role of nutritional sufficiency and drug – nutraceutical combinations of vitamin D |
Authors: | Deepa, P. R. Tare, Meghana |
Keywords: | Biology Vitamin D COVID-19 Obesity Kawasaki disease Stroke |
Issue Date: | Mar-2023 |
Publisher: | Elsevier |
Abstract: | The vulnerability of human health is amplified in recent times with global increase in non-communicable diseases (due to lifestyle changes and environmental insults) and infectious diseases (caused by newer pathogens and drug-resistance strains). Clinical management of diseases is further complicated by disease severity caused by other comorbid factors. Drug-based therapy may not be the sole approach, particularly in scenarios like the COVID-19 pandemic, where there is no specific drug against SARS-CoV-2. Nutritional interventions are significant in armouring human populations in disease prevention, and as adjunctive therapy for disease alleviation. Amidst ongoing clinical trials to determine the efficacy of Vit. D against infections and associated complications, this review examines the pleiotropic benefits of nutritional adequacy of vitamin D (Vit. D) in combating viral infections (COVID-19), its severity and complications due to co-morbidities (obesity, diabetes, stroke and Kawasaki disease), based on research findings and clinical studies. Supplements of Vit. D in combination with other nutrients, and drugs, are suggested as promising preventive-health and adjunct-treatment strategies in the clinical management of viral infections with metabolic comorbidities. |
URI: | https://www.sciencedirect.com/science/article/pii/S2666149722000421?via%3Dihub http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/15394 |
Appears in Collections: | Department of Biological Sciences |
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