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Please use this identifier to cite or link to this item: http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/15422
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dc.contributor.authorTare, Meghana-
dc.date.accessioned2024-09-04T09:14:35Z-
dc.date.available2024-09-04T09:14:35Z-
dc.date.issued2021-01-
dc.identifier.urihttps://www.nature.com/articles/s41598-021-81261-0-
dc.identifier.urihttp://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/15422-
dc.description.abstractThe initiator caspase Dronc is the only CARD-domain containing caspase in Drosophila and is essential for apoptosis. Here, we report that homozygous dronc mutant adult animals are short-lived due to the presence of a poorly developed, defective and leaky intestine. Interestingly, this mutant phenotype can be significantly rescued by enteroblast-specific expression of dronc+ in dronc mutant animals, suggesting that proper Dronc function specifically in enteroblasts, one of four cell types in the intestine, is critical for normal development of the intestine. Furthermore, enteroblast-specific knockdown of dronc in adult intestines triggers hyperplasia and differentiation defects. These enteroblast-specific functions of Dronc do not require the apoptotic pathway and thus occur in a non-apoptotic manner. In summary, we demonstrate that an apoptotic initiator caspase has a very critical non-apoptotic function for normal development and for the control of the cell lineage in the adult midgut and therefore for proper physiology and homeostasis.en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.subjectBiologyen_US
dc.subjectDrosophila intestineen_US
dc.subjectHomeostasisen_US
dc.titleNon-apoptotic enteroblast-specific role of the initiator caspase Dronc for development and homeostasis of the Drosophila intestineen_US
dc.typeArticleen_US
Appears in Collections:Department of Biological Sciences

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