![DSpace logo](/jspui/image/logo.gif)
Please use this identifier to cite or link to this item:
http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/15493
Title: | Quinoline Glycoconjugates as Potentially Anticancer and Anti-Inflammatory Agents: An Investigation Involving Synthesis, Biological Screening, and Docking |
Authors: | Sah, Ajay Kumar |
Keywords: | Chemistry Glycoconjugates Biological Screening Synthesis |
Issue Date: | Aug-2020 |
Publisher: | Wiley |
Abstract: | The present work is a preliminary report of synthesis of a series of targeted 4,6-O-ethylidene-β-D-glucopyranosylamine glycoconjugate quinoline 4-carboxylic acid derivatives followed by a quick evaluation of their anti-inflammatory and anticancer activities. Compounds C5 and C8 exhibited highest anti-inflammatory activity against human COX-2 enzyme. Anticancer studies were also performed in vitro which revealed C8 as a promising candidate against HeLa, human cervical cancer cell lines. The anti-inflammatory and anticancer activity was further confirmed by molecular docking studies for all the synthesized molecules. That all the compounds showed potency, seems to validate our initial hypothesis concerning a positive correlation between anticancer and anti-inflammatory activity for the designed quinoline glycoconjugates. |
URI: | https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/slct.202002345 http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/15493 |
Appears in Collections: | Department of Chemistry |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.