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Please use this identifier to cite or link to this item: http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/15508
Title: Ball-Milling-Enabled Zn(OTf)2-Catalyzed Friedel–Crafts Hydroxyalkylation of Imidazo[1,2-a]pyridines and Indoles
Authors: Kumar, Anil
Keywords: Chemistry
Chemical Reactions
Ethyl groups
Indoles
Pyridines
Silica Nanoparticles (SiNP)
Issue Date: Feb-2023
Publisher: ACS
Abstract: A facile and efficient synthetic method for the construction of C3-hydroxyalkylated imidazo[1,2-a]pyridines and indoles by a Zn(OTf)2-catalyzed Friedel–Crafts hydroxyalkylation of imidazo[1,2-a]pyridines and indoles with carbonyl compounds under mechanochemical conditions is reported. Good product selectivity, shorter reaction time, ambient reaction temperature, tolerance of a wide range of functional groups, broad substrate scope, moderate to good yield of products, and scalability are the salient features of the developed methodology.
URI: https://pubs.acs.org/doi/10.1021/acs.joc.2c02719
http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/15508
Appears in Collections:Department of Chemistry

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