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Please use this identifier to cite or link to this item: http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/15532
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dc.contributor.authorKumar, Dalip-
dc.date.accessioned2024-09-11T09:27:07Z-
dc.date.available2024-09-11T09:27:07Z-
dc.date.issued2022-11-
dc.identifier.urihttps://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cmdc.202200405-
dc.identifier.urihttp://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/15532-
dc.description.abstractSix methyl pheophorbide-a derivatives were prepared by linking a tryptamine side chain at the C-131, C-152 and C-173 positions of pheophorbide-a. Prepared conjugates were characterized and evaluated for their photocytotoxicity against A549 cells. The conjugate 6 a with strong absorption at 413 nm (Soret band), 663–671 nm (Q bands) and comparable fluorescence quantum yield (0.26) was found to exhibit significant cytotoxicity (659 nM). Molecular integration of pheophorbide-a and tryptamines showed synergistic effects as the most potent conjugate 6 a was identified with enhanced photocytotoxicity when compared to methyl pheophorbide-a. The conjugate 6 a was smoothly taken up by A549 cells and exhibited intracellular localization predominantly to lysosome in the cytoplasm. Upon photoirradiation 6 a generated singlet oxygen to show potent cytotoxicity toward A549 cells.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectChemistryen_US
dc.subjectPhotosensitizersen_US
dc.subjectPhotodynamic therapyen_US
dc.subjectSynthesisen_US
dc.titleSynthesis of Red-Light-Responsive Pheophorbide-a Tryptamine Conjugated Photosensitizers for Photodynamic Therapyen_US
dc.typeArticleen_US
Appears in Collections:Department of Chemistry

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