DSpace logo

Please use this identifier to cite or link to this item: http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/15538
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKumar, Dalip-
dc.contributor.authorKumar, Indresh-
dc.date.accessioned2024-09-11T10:09:00Z-
dc.date.available2024-09-11T10:09:00Z-
dc.date.issued2020-10-
dc.identifier.urihttps://pubs.acs.org/doi/10.1021/acs.joc.0c02141-
dc.identifier.urihttp://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/15538-
dc.description.abstractA direct protocol for the asymmetric synthesis of dibenzoxazepine/thiazepine-fused [2.2.2] isoquinuclidines is developed. The reaction proceeds through a proline-catalyzed direct Mannich reaction followed by an intramolecular aza-Michael cascade sequence between 2-cyclohexene-1-one and various tricyclic imines, like dibenzoxazepines/thiazepines, as an overall [4 + 2] aza-Diels–Alder reaction. A series of pentacyclic isoquinuclidines have been prepared, with complete endo-selectivity, in good to high yields and excellent enantioselectivity (>99:1). Density functional theory (DFT) calculations further support the observed high stereochemical outcome of the reaction.en_US
dc.language.isoenen_US
dc.publisherACSen_US
dc.subjectChemistryen_US
dc.subjectAddition reactionsen_US
dc.subjectChemical reactionsen_US
dc.subjectFossil fuelsen_US
dc.subjectPurificationen_US
dc.subjectStereoselectivityen_US
dc.titleDirect Amine-Catalyzed Enantioselective Synthesis of Pentacyclic Dibenzo[b,f][1,4]oxazepine/Thiazepine-Fused Isoquinuclidines along with DFT Calculationsen_US
dc.typeArticleen_US
Appears in Collections:Department of Chemistry

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.