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Please use this identifier to cite or link to this item: http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/15548
Title: Two-pot synthesis and photophysical studies of 1,6-disubstituted 5-aza-indoles from succinaldehyde and N-aryl propargylic-imines
Authors: Kumar, Indresh
Keywords: Synthesis
Chemistry
Succinaldehyde
Issue Date: 2021
Publisher: RSC
Abstract: A two-pot synthesis of 5-aza-indoles has been developed from aqueous succinaldehyde and N-aryl propargylic-imines. This overall protocol involves: (i) the metal-free [3 + 2] annulation of aqueous succinaldehyde and N-aryl propargylic-imines to access 2-alkynyl-pyrrole-3-aldehydes and (ii) Ag-catalyzed 6-endo-dig-cyclization to obtain substituted 5-aza-indoles in the second pot. The 5-aza-indoles showed engaging photophysical activities, and the practicality of this pot-economic gram-scale synthesis has been demonstrated.
URI: https://pubs.rsc.org/en/content/articlelanding/2021/ob/d1ob01949j
http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/15548
Appears in Collections:Department of Chemistry

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