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Please use this identifier to cite or link to this item: http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/15553
Title: Direct catalytic synthesis of β-(C3)-substituted pyrroles: a complementary addition to the Paal–Knorr reaction
Authors: Kumar, Indresh
Keywords: Chemistry
Synthesis
Paal–Knorr reaction
Issue Date: 2021
Publisher: RSC
Abstract: The synthesis of β-(C3)-functionalized pyrroles is a challenging task and requires a multistep protocol. An operationally simple direct catalytic synthesis of β-substituted pyrroles has been developed. This one-pot multicomponent method combined aqueous succinaldehyde as 1,4-dicarbonyl, primary amines, and isatins to access hydroxyl-oxindole β-tethered pyrroles. Direct synthesis of the β-substituted free NH-pyrrole is the central intensity of this work. DFT-calculations and preliminary mechanism investigation support the possible reaction pathway.
URI: https://pubs.rsc.org/en/content/articlehtml/2021/cc/d0cc06357f
http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/15553
Appears in Collections:Department of Chemistry

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