Rhodium-Catalyzed Annulation of Vinylated Tyrosines with Internal Alkynes to Access Oxepine-Mounted Unnatural Tyrosines and Its Peptide Late Stage Functionalization

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DC Field	Value	Language
dc.contributor.author	Sakhuja, Rajeev	-
dc.date.accessioned	2024-09-13T08:54:22Z	-
dc.date.available	2024-09-13T08:54:22Z	-
dc.date.issued	2022-09	-
dc.identifier.uri	https://pubs.acs.org/doi/10.1021/acs.orglett.2c02820	-
dc.identifier.uri	http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/15568	-
dc.description.abstract	A Rh(III)-catalyzed [5+2] annulation of vinyl tyrosines with symmetrical and unsymmetrical internal alkynes was achieved, furnishing a series of oxepine-mounted tyrosine-based unnatural amino acids. In addition, the chemical applicability of the developed strategy was exemplified by stapling amino acid/peptide-appended alkynes with vinyl tyrosines and late stage functionalization of tyrosine-containing dipeptides and tripeptide with internal alkynes.	en_US
dc.language.iso	en	en_US
dc.publisher	ACS	en_US
dc.subject	Chemistry	en_US
dc.subject	Annulations	en_US
dc.subject	Aromatic compounds	en_US
dc.subject	Hydrocarbons	en_US
dc.subject	Peptides and proteins	en_US
dc.title	Rhodium-Catalyzed Annulation of Vinylated Tyrosines with Internal Alkynes to Access Oxepine-Mounted Unnatural Tyrosines and Its Peptide Late Stage Functionalization	en_US
dc.type	Article	en_US
Appears in Collections:	Department of Chemistry

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