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Please use this identifier to cite or link to this item: http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/18401
Title: Basic nitrogen (BaN): a ‘privileged element’ in medicinal chemistry
Authors: Sundriyal, Sandeep
Keywords: Pharmacy
Pharmacokinetics
Nitrogen-heterocycles
Medicinal chemists
Issue Date: Oct-2024
Publisher: Taylor & Francis
Abstract: Medicinal chemists continuously search for small molecules with ideal pharmacokinetic and pharmacodynamic (PKPD) profiles. This quest has resulted in several efforts to understand and define ‘druglikeness’ or ‘drug-like chemical space’. Favorable drug-living system interactions ultimately depend on a compound's chemical structure. Hence, studying patterns and correlations between compound structure and PKPD parameters to derive common denominators is an obvious strategy [Citation1]. Since the publication of ‘Lipinski’s rule of five’ [Citation2], our understanding of the correlation between druglikeness and different physicochemical properties has evolved. Consequently, several guidelines have been suggested for selecting ‘quality’ compounds to improve success rates in preclinical and clinical studies.
URI: https://www.tandfonline.com/doi/full/10.1080/17568919.2024.2409627
http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/18401
Appears in Collections:Department of Pharmacy

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