Organo-catalyzed enantioselective [4+2] Annulation of glutaraldehyde and c3-indolyl-imines to access indol-3-yl-piperidines

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DC Field	Value	Language
dc.contributor.author	Kumar, Indresh	-
dc.date.accessioned	2025-07-25T07:09:09Z	-
dc.date.available	2025-07-25T07:09:09Z	-
dc.date.issued	2023-10	-
dc.identifier.uri	https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.202300901	-
dc.identifier.uri	http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/19091	-
dc.description.abstract	A simple and straightforward method is developed for the enantioselective synthesis of indol-3-yl-piperidine. The reaction proceeds through a proline-catalyzed direct Mannich reaction between glutaraldehyde and C3-indolyl-imines, followed by intramolecular reductive cyclization as an overall [4+2] annulation in one-pot fashion. A series of indol-3-yl-piperidine have been accessed with good yields up to 71 % and high enantioselectivity up to >99 % ee.	en_US
dc.language.iso	en	en_US
dc.publisher	Wiley	en_US
dc.subject	Chemistry	en_US
dc.subject	Indol-3-yl-piperidine	en_US
dc.subject	Enantioselective synthesis	en_US
dc.subject	Reductive cyclization	en_US
dc.subject	Glutaraldehyde	en_US
dc.title	Organo-catalyzed enantioselective [4+2] Annulation of glutaraldehyde and c3-indolyl-imines to access indol-3-yl-piperidines	en_US
dc.type	Article	en_US
Appears in Collections:	Department of Chemistry

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