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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sakhuja, Rajeev | - |
dc.date.accessioned | 2025-07-30T06:39:59Z | - |
dc.date.available | 2025-07-30T06:39:59Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.uri | https://pubs.acs.org/doi/full/10.1021/acs.orglett.3c02994 | - |
dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/19112 | - |
dc.description.abstract | Pyridyloxy-directed Rh(III)-catalyzed regioselective C3Ar–H alkenylation of protected tyrosines was achieved with N-aryl and N-alkyl maleimides, furnishing a series of maleimide-appended tyrosine-based unnatural amino acids in good yields. Further, the late-stage exemplification of the strategy was successfully accomplished on tyrosine-containing dipeptides, tripeptides, and tetrapeptides in moderate reactivity. Also, the chemical applications of the strategy were successfully executed toward nailing tyrosine with other amino acids via a maleimide linker and intramolecular hydroarylation to produce tyrosine-centered stapled products and succinimide-glued macrocyclized products, respectively. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ACS | en_US |
dc.subject | Chemistry | en_US |
dc.subject | Additives | en_US |
dc.subject | Functionalization | en_US |
dc.subject | Monomers | en_US |
dc.subject | Organic reactions | en_US |
dc.subject | Peptides and proteins | en_US |
dc.title | Rhodium-catalyzed regioselective C3ar functionalization of tyrosines with maleimides and its late-stage peptide exemplification | en_US |
dc.type | Article | en_US |
Appears in Collections: | Department of Chemistry |
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