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Please use this identifier to cite or link to this item: http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/19112
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dc.contributor.authorSakhuja, Rajeev-
dc.date.accessioned2025-07-30T06:39:59Z-
dc.date.available2025-07-30T06:39:59Z-
dc.date.issued2023-10-
dc.identifier.urihttps://pubs.acs.org/doi/full/10.1021/acs.orglett.3c02994-
dc.identifier.urihttp://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/19112-
dc.description.abstractPyridyloxy-directed Rh(III)-catalyzed regioselective C3Ar–H alkenylation of protected tyrosines was achieved with N-aryl and N-alkyl maleimides, furnishing a series of maleimide-appended tyrosine-based unnatural amino acids in good yields. Further, the late-stage exemplification of the strategy was successfully accomplished on tyrosine-containing dipeptides, tripeptides, and tetrapeptides in moderate reactivity. Also, the chemical applications of the strategy were successfully executed toward nailing tyrosine with other amino acids via a maleimide linker and intramolecular hydroarylation to produce tyrosine-centered stapled products and succinimide-glued macrocyclized products, respectively.en_US
dc.language.isoenen_US
dc.publisherACSen_US
dc.subjectChemistryen_US
dc.subjectAdditivesen_US
dc.subjectFunctionalizationen_US
dc.subjectMonomersen_US
dc.subjectOrganic reactionsen_US
dc.subjectPeptides and proteinsen_US
dc.titleRhodium-catalyzed regioselective C3ar functionalization of tyrosines with maleimides and its late-stage peptide exemplificationen_US
dc.typeArticleen_US
Appears in Collections:Department of Chemistry

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