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Title: | Rhodium-catalyzed functionalization and annulation of N-aryl phthalazinediones with allyl alcohols |
Authors: | Sakhuja, Rajeev |
Keywords: | Chemistry Rh(III)-catalyzed C−H activation Direct ortho‑Csp2–H acylalkylation Indazolo[1,2‑b]phthalazine diones |
Issue Date: | Aug-2024 |
Publisher: | Wiley |
Abstract: | A direct ortho-Csp2-H acylalkylation of 2-aryl-2,3-dihydrophthalazine-1,4-diones with unsubstituted and substituted allyl alcohols is achieved in high yields through Rh(III)-catalyzed C−H bond activation process. The additional employment of Cu(OAc)2⋅2H2O as an oxidant detour the reaction towards [4+1] annulation, producing 13-(2-oxopropyl)-13H-indazolo[1,2-b]phthalazine-6,11-diones in moderate yields. Interestingly, Lawesson's reagent-mediated conditions accomplished intramolecular cyclization in ortho-(formylalkylated)-2,3-dihydrophthalazine-1,4-diones to produce diazepino[1,2-b]phthalazine-diones in moderate yields. Furthermore, allyl alcohol showcased distinct reactivity in presence of different additives to produce ortho-allylated, oxidative and non-oxidative [4+2] annulated products. |
URI: | https://aces.onlinelibrary.wiley.com/doi/full/10.1002/asia.202400711 http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/19187 |
Appears in Collections: | ABG NEWS |
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