Collection's Items (Sorted by Submit Date in Descending order): 1 to 20 of 868
| Issue Date | Title | Author(s) |
| 2024-08 | Label-free GaN HEMT-based biosensing platform for interferon-γ detection | Taliyan, Rajeev |
| 2024-06 | Pharmacokinetic and Biodistribution Studies of Camel Milk Casein Nanoparticles Loaded Sorafenib in Swiss Albino Mice | Taliyan, Rajeev; Dubey, Uma S. |
| 2024-11 | Immunological challenges and opportunities in glioblastoma multiforme: A comprehensive view from immune system lens | Singhvi, Gautam; Taliyan, Rajeev |
| 2024-12 | Neuroprotective potential of Epigenetic modulators, its regulation and therapeutic approaches for the management of Parkinson's disease | Taliyan, Rajeev |
| 2025-01 | Millions of people worldwide are negatively impacted by a diverse range of brain conditions known as neurodegenerative diseases. The work reports a GaN HEMT-based biosensing system for the early detection and monitoring of neurodegenerative disease biomarkers in clinically relevant concentration ranges. The developed system offers a high sensitivity of 19.40 µA/pg/ml, 0.52 mA/pg/ml, 0.69 mA/ng/ml, 0.13 mA/pg/ml, 23.66 µA/pg/ml, and 23.85 µA/pg/ml for the detection of UCH-L1, GFAP, S100B, IL-6, Aβ, and IFN-γ respectively. The proposed biofunctionalization assay has an excellent specificity and selectivity, signal-to-noise ratio of 1:16, 1:23, and 1:38 for UCH-L1, GFAP, and S100B detection respectively with a LoD of 0.06 fg/ml. The platform has good repeatability with an average sensitivity of 19.41 µA/pg/ml, 0.524 mA/pg/ml, and 0.704 mA/ng/ml for UCH-L1, GFAP, and S100B detection respectively. The sensors have a very good shelf-life for a storage time of 35 days with reductions of 1.39 %, 1.72 %, and 2.05 % in sensor response and 2.88 %, 2.76 %, and 2.96 % in sensitivity for UCH-L1, GFAP, and S100B respectively. The coefficient of variation (CV) values for conventional and meander-gated GaN HEMT biosensors were found to be ∼0.038 and ∼0.026 respectively. A slight variation of ∼4.41 % in sensor response when the sensor was reused clearly demonstrates the sensor’s reusability. A very high resolution with detection capability in the ultra-low concentration of fg/ml with good linearity and quantifiable sensor response which is a key requirement for early-stage detection of diseases has been observed for sensor design with source-to-drain distance () of 10 µm. Thus, the platform capability and suitability for early detection and prognosis of neurodegenerative disease detection and monitoring have been demonstrated. Further, the system can be imperative in patient screening in clinical, sports, and warfare for CT or MRI scan requirements. | Taliyan, Rajeev |
| 2025-01 | Neurodegenerative diseases early detection and monitoring system for point-of-care applications | Taliyan, Rajeev |
| 2025 | Design aspects, development, and sensitivity analysis of gan hemt-based biosensing platform for label-free detection of interleukin-6 | Taliyan, Rajeev |
| 2025-01 | Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications | Taliyan, Rajeev |
| 2022-09 | Kynurenine monooxygenase inhibition and associated reduced quinolinic acid reverses depression-like behaviour by upregulating Nrf2/ARE pathway in mouse model of depression: In-vivo and In-silico studies | Khare, Pragyanshu |
| 2024-07 | Topical menthol, a pharmacological cold mimic, induces cold sensitivity, adaptive thermogenesis and brown adipose tissue activation in mice | Khare, Pragyanshu |
| 2024-11 | The TRPC5 receptor as pharmacological target for pain and metabolic disease | Khare, Pragyanshu |
| 2024 | Nanoparticle-based materials for wound management | Pandey, Murali Monohar |
| 2024-04 | In situ bioprinting: process, bioinks, and applications | Pandey, Murali Monohar |
| 2024-11 | Oxidized ionic polysaccharide hydrogels: review on derived scaffolds characteristics and tissue engineering applications | Pandey, Murali Monohar |
| 2023-05 | Acetylcholine structure-based small activatable fluorogenic probe for specific detection of acetylcholinesterase | Sidhu, Jagpreet Singh |
| 2023-11 | Unraveling the Conversion of Fatty Acids into Terminal Alkenes by an Integral Membrane Enzyme, UndB | Sidhu, Jagpreet Singh |
| 2024-11 | Phenoxy-1,2-dioxetane-based activatable chemiluminescent probes: tuning of photophysical properties for tracing enzymatic activities in living cells | Sidhu, Jagpreet Singh; Taliyan, Rajeev |
| 2024-01 | Investigation of antibacterial potential of Natsiatum herpeticum Buch.-Ham. ex Arn. using in silico-in vitro approach | Jadhav, Hemant R. |
| 2024-07 | Unveiling the potential of novel indol-3-yl-phenyl allylidene hydrazine carboximidamide derivatives as AChE/BACE 1 dual inhibitors: a combined in silico, synthesis and in vitro study | Jadhav, Hemant R. |
| 2024-08 | Design, synthesis, in silico, and in vitro evaluation of pyrrol-2-yl-phenyl allylidene hydrazine carboximidamide derivatives as AChE/BACE 1 dual inhibitors | Jadhav, Hemant R. |
Collection's Items (Sorted by Submit Date in Descending order): 1 to 20 of 868
