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http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/20506| Title: | DRP1-mediated mitochondrial dynamics orchestrate EMT in glioblastoma cells |
| Authors: | Chowdhury, Shibasish Chowdhury, Rajdeep Mukherjee, Sudeshna |
| Keywords: | Biology Epithelial–mesenchymal transition (EMT) Glioblastoma multiforme (GBM) Mitochondrial dynamics Cytoskeletal regulation |
| Issue Date: | Dec-2025 |
| Abstract: | Epithelial to mesenchymal transition (EMT), a differentiation process, frequently imparts invasive properties in Glioblastoma Multiforme (GBM), which leads to a poor prognosis. Cells lose apical-basal polarity, cell-cell connections, and/or chemo-resistance during EMT, which can result in the spread of cancer and the acquisition of additional stem cell-like traits. It is unclear how organelle dynamics influence EMT in this respect. The interaction between cytoskeletal and mitochondrial regulators governing GBM cell EMT is explored in this article. |
| URI: | https://www.biorxiv.org/content/10.64898/2025.12.12.694080v1.abstract http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/20506 |
| Appears in Collections: | Department of Biological Sciences |
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