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http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/2141| Title: | Verteporfin disrupts multiple steps of autophagy and regulates p53 to sensitize osteosarcoma cells |
| Authors: | Chowdhury, Rajdeep Chowdhury, Shibasish Mukherjee, Sudeshna |
| Keywords: | Biology Verteporfin Autophagy Osteosarcoma cells |
| Issue Date: | Jan-2021 |
| Publisher: | Springer Nature |
| Abstract: | Osteosarcoma (OS) is a malignant tumor of the bone mostly observed in children and adolescents. The current treatment approach includes neoadjuvant and adjuvant chemotherapy; however, drug resistance often hinders therapy in OS patients. Also, the post-relapse survival of OS patients is as low as 20%. We therefore planned to understand the molecular cause for its poor prognosis and design an appropriate therapeutic strategy to combat the disease. |
| URI: | https://cancerci.biomedcentral.com/articles/10.1186/s12935-020-01720-y http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2141 |
| Appears in Collections: | Department of Biological Sciences |
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