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Please use this identifier to cite or link to this item: http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/2327
Title: Drug Tolerant Cells: An Emerging Target With Unique Transcriptomic Features
Authors: Chowdhury, Rajdeep
Majumder, Syamantak
Chowdhury, Shibasish
Keywords: Biology
Osteosarcomax
Osteosarcoma
RNA sequencing
Drug resistance
Drug-tolerant persister
Issue Date: 2019
Publisher: Sage
Abstract: Long-term outcome of cancer therapy is often severely perturbed by the acquisition of drug resistance. Recent evidence point toward the survival of a subpopulation of tumor cells under acute drug stress that over time can re-populate the tumor. These transiently existing, weakly proliferative, drug-tolerant cells facilitate tumor cell survival until more stable resistance mechanisms are acquired. From a therapeutic perspective, understanding the molecular features of the tolerant cells is critical to attenuation of resistance. In this article, we discuss the transcriptomic features of drug-tolerant osteosarcoma cells that survive a high dose of cisplatin shock. We present the unique transcriptome of the minimally dividing tolerant cells in comparison with the proliferative persisters or resistant cells derived from the tolerant cells. Targeting the tolerant cells can represent an efficient therapeutic strategy impeding tumor recurrence.
URI: https://journals.sagepub.com/action/doSearch?target=default&ContribAuthorStored=Majumder%2C+Syamantak
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2327
Appears in Collections:Department of Biological Sciences

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