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Title: | Fast Microwave Assisted Synthesis of Pyranopyrazole Derivatives as New Anticancer Agents |
Authors: | Chowdhury, Rajdeep Shukla, Paritosh |
Keywords: | Biology Microwave Pyranopyrazoles Anticancer Green Chemistry Microwave assisted synthesis |
Issue Date: | 2016 |
Publisher: | Bentham Science |
Abstract: | A series of compounds having the pyranopyrazole pharmacophore were synthesised by the traditional method and then by an unreported rapid four-component microwave assisted method. The microwave strategy required substantially shorter reaction times as compared to the traditional method. The prepared molecules were tested in-vitro for their cytotoxic activity against the Hep3B cancer cell lines. The activity results were subsequently rationalized for a quick structure-activity relationship leading to the conclusion that the presence of certain heteroatom substituents at a 3-position of the pharmacophore may be crucial for anticancer potency. |
URI: | https://www.eurekaselect.com/127787/article?tracking-code=4 http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2345 |
Appears in Collections: | Department of Biological Sciences |
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