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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chowdhury, Rajdeep | - |
dc.contributor.author | Shukla, Paritosh | - |
dc.date.accessioned | 2021-09-27T08:10:50Z | - |
dc.date.available | 2021-09-27T08:10:50Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://www.eurekaselect.com/127787/article?tracking-code=4 | - |
dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2345 | - |
dc.description.abstract | A series of compounds having the pyranopyrazole pharmacophore were synthesised by the traditional method and then by an unreported rapid four-component microwave assisted method. The microwave strategy required substantially shorter reaction times as compared to the traditional method. The prepared molecules were tested in-vitro for their cytotoxic activity against the Hep3B cancer cell lines. The activity results were subsequently rationalized for a quick structure-activity relationship leading to the conclusion that the presence of certain heteroatom substituents at a 3-position of the pharmacophore may be crucial for anticancer potency. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Bentham Science | en_US |
dc.subject | Biology | en_US |
dc.subject | Microwave | en_US |
dc.subject | Pyranopyrazoles | en_US |
dc.subject | Anticancer | en_US |
dc.subject | Green Chemistry | en_US |
dc.subject | Microwave assisted synthesis | en_US |
dc.title | Fast Microwave Assisted Synthesis of Pyranopyrazole Derivatives as New Anticancer Agents | en_US |
dc.type | Article | en_US |
Appears in Collections: | Department of Biological Sciences |
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