Quinoline Glycoconjugates as Potentially Anticancer and Anti-Inflammatory Agents: An Investigation Involving Synthesis, Biological Screening, and Dockin

Abstract

The present work is a preliminary report of synthesis of a series of targeted 4,6-O-ethylidene-β-D-glucopyranosylamine glycoconjugate quinoline 4-carboxylic acid derivatives followed by a quick evaluation of their anti-inflammatory and anticancer activities. Compounds C5 and C8 exhibited highest anti-inflammatory activity against human COX-2 enzyme. Anticancer studies were also performed in vitro which revealed C8 as a promising candidate against HeLa, human cervical cancer cell lines. The anti-inflammatory and anticancer activity was further confirmed by molecular docking studies for all the synthesized molecules. That all the compounds showed potency, seems to validate our initial hypothesis concerning a positive correlation between anticancer and anti-inflammatory activity for the designed quinoline glycoconjugates.