![DSpace logo](/jspui/image/logo.gif)
Please use this identifier to cite or link to this item:
http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/2774
Title: | Synthesis of Mefenamic Acid Containing N-Glycoconjugates and Their Evaluation as Human COX-2 Enzyme Inhibitor |
Authors: | Sah, Ajay Kumar |
Keywords: | Chemistry Synthesis Mefenamic Acid Containing Enzyme Inhibitor |
Issue Date: | 17-Feb-2020 |
Publisher: | Wiley |
Abstract: | A series of d-glucose derived N-glycopeptides containing mefenamic acid have been synthesised and in vitro evaluation of all these molecules have been performed as COX-2 (human) enzyme inhibitor using Enzymes Immuno Assay kit. These studies were further supported by docking experiments on human COX-2 enzyme (PDB ID: 5IKR). All the compounds exhibited a fair amount of COX-2 enzyme inhibition during both the modes of study and tryptophan derivative showed the best activity. Acute toxicity (LD50) in rat has also been evaluated using General Unrestricted Structure-Activity Relationships (GUSAR) software, where acute oral toxicity for most of the molecules was found to be less than the pure mefenamic acid. |
URI: | https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/slct.201904655 http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2774 |
Appears in Collections: | Department of Chemistry |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.