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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sah, Ajay Kumar | - |
dc.date.accessioned | 2021-10-14T13:07:11Z | - |
dc.date.available | 2021-10-14T13:07:11Z | - |
dc.date.issued | 2020-02-17 | - |
dc.identifier.uri | https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/slct.201904655 | - |
dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2774 | - |
dc.description.abstract | A series of d-glucose derived N-glycopeptides containing mefenamic acid have been synthesised and in vitro evaluation of all these molecules have been performed as COX-2 (human) enzyme inhibitor using Enzymes Immuno Assay kit. These studies were further supported by docking experiments on human COX-2 enzyme (PDB ID: 5IKR). All the compounds exhibited a fair amount of COX-2 enzyme inhibition during both the modes of study and tryptophan derivative showed the best activity. Acute toxicity (LD50) in rat has also been evaluated using General Unrestricted Structure-Activity Relationships (GUSAR) software, where acute oral toxicity for most of the molecules was found to be less than the pure mefenamic acid. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.subject | Chemistry | en_US |
dc.subject | Synthesis | en_US |
dc.subject | Mefenamic Acid Containing | en_US |
dc.subject | Enzyme Inhibitor | en_US |
dc.title | Synthesis of Mefenamic Acid Containing N-Glycoconjugates and Their Evaluation as Human COX-2 Enzyme Inhibitor | en_US |
dc.type | Article | en_US |
Appears in Collections: | Department of Chemistry |
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