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http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/2806| Title: | TEMPO-Mediated Cross-Dehydrogenative Coupling of Indoles and Imidazo[1,2-a]pyridines with Fluorinated Alcohols |
| Authors: | Kumar, Anil |
| Keywords: | Chemistry Functionalization Indoles Chemical reactions |
| Issue Date: | 2021 |
| Publisher: | ACS |
| Abstract: | A simple and highly efficient metal-free method has been developed for hydroxyfluoroalkylation of indoles and imidazo[1,2-a]pyridines via TEMPO-mediated C(sp3)–H and C(sp2)–H bond cross-dehydrogenative coupling of fluorinated alcohols and indoles. The protocol showed broad substrate scope, afforded good yields of hydroxyfluoroalkylated products, and was amenable for scale-up. Mechanistic investigation indicated involvement of the radical pathway. |
| URI: | https://pubs.acs.org/doi/abs/10.1021/acs.orglett.1c00031 http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2806 |
| Appears in Collections: | Department of Chemistry |
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