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Title: | KOH-mediated intramolecular amidation and sulfenylation: A direct approach to access 3-(arylthio)imidazo[1,2-a]pyridin-2-ols |
Authors: | Kumar, Anil |
Keywords: | Chemistry Bromides Methodology Pyridines Thiols Utilities |
Issue Date: | 2020 |
Publisher: | USDA |
Abstract: | A simple and facile method for the synthesis of 3-(arylthio)imidazo[1,2-a]pyridin-2-ols has been developed by a KOH-mediated reaction of 2-aminopyridinium bromides with aryl thiols. The method afforded a wide range of 3-(arylthio)imidazo[1,2-a]pyridin-2-ols in moderate to excellent (56–95%) yields with excellent functional group tolerance. Synthetic utility of the protocol was demonstrated by gram-scale reaction and preparation of 2-aryl-3-(p-tolylthio)imidazo[1,2-a]pyridines from 3-(p-tolylthio)imidazo[1,2-a]pyridin-2-ol. |
URI: | https://pubag.nal.usda.gov/catalog/7074024 http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2814 |
Appears in Collections: | Department of Chemistry |
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