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Title: | Dual Role of Glyoxal in Metal-Free Dicarbonylation Reaction: Synthesis of Symmetrical and Unsymmetrical Dicarbonyl Imidazoheterocycles |
Authors: | Kumar, Anil |
Keywords: | Chemistry Organic acids Substituents Chemical reactions Organic reactions Phenyls |
Issue Date: | Jun-2019 |
Publisher: | ACS |
Abstract: | A practical and efficient method has been developed for the dicarbonylation of imidazoheterocycles using glyoxals as dicarbonyl precursors under metal-free conditions in acetic acid. A series of symmetrical and unsymmetrical dicarbonyl imidazoheterocycles was synthesized in good yields. Aryl and alkyl glyoxals also demonstrated excellent reactivity under similar reaction conditions and delivered corresponding dicarbonyl imidazoheterocycles in high yields. It is believed that the glyoxal plays a dual role both as a dicarbonyl source and as an oxidant in this transformation. A probable mechanistic pathway has been proposed based on control experiments and electrospray ionization high-resolution mass spectrometry analysis. |
URI: | https://pubs.acs.org/doi/abs/10.1021/acsomega.9b00716 http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2820 |
Appears in Collections: | Department of Chemistry |
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