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Title: | Copper and palladium-catalyzed sequential reactions: one-pot synthesis of isoindolo[2,1-b]isoquinolin-7(5H)-ones |
Authors: | Kumar, Anil |
Keywords: | Chemistry Copper Palladium-catalyzed Isoindolo |
Issue Date: | 2019 |
Publisher: | RSC |
Abstract: | A highly efficient protocol has been developed for the synthesis of diversely substituted isoindolo[2,1-b]isoquinolin-7(5H)-ones through sequential Cu(II)-catalyzed Sonogashira coupling, intramolecular hydroamidation followed by palladium-catalyzed ligand-free Heck reaction. Good to excellent yields (41–94%) were observed with excellent substrate scope and functional group tolerance. The developed method represents a practical strategy for the construction of bioactive isoindolo[2,1-b]isoquinolin-7(5H)-ones. |
URI: | https://pubs.rsc.org/en/content/articlelanding/2019/ob/c9ob00440h http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2821 |
Appears in Collections: | Department of Chemistry |
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