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Title: | Synthesis of imidazopyridine-fused indoles via one-pot sequential Knoevenagel condensation and cross dehydrogenative coupling |
Authors: | Kumar, Anil Kumar, Dalip |
Keywords: | Chemistry Synthesis Imidazopyridine-fused indoles Dehydrogenative coupling |
Issue Date: | 2018 |
Publisher: | RSC |
Abstract: | A simple and efficient strategy for the synthesis of imidazopyridine-fused indoles has been developed that involves one-pot sequential Knoevenagel condensation of readily available active methylene azoles with N-substituted-1H-indole-3-carboxaldehydes or N-substituted-1H-indole-2-carboxaldehydes followed by palladium-catalyzed intramolecular cross dehydrogenative coupling reaction. A series of 36 derivatives was prepared by using this strategy. The products were obtained in moderate to excellent (32–94%) yields and showed broad substrate scope with tolerance of various functional groups and was amiable for gram scale preparation without problems. |
URI: | https://pubs.rsc.org/en/content/articlelanding/2018/ob/c8ob01449c http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2825 |
Appears in Collections: | Department of Chemistry |
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