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Title: | Nickel-Catalyzed Tandem Knoevenagel Condensation and Intramolecular Direct Arylation: Synthesis of Pyrazolo[5,1-a]-isoquinoline Derivatives |
Authors: | Kumar, Anil Kumar, Dalip |
Keywords: | Chemistry Nickel-Catalyzed Synthesis of Pyrazolo |
Issue Date: | 5-Mar-2018 |
Publisher: | Wiley |
Abstract: | A simple and efficient method for the synthesis of pyrazolo[5,1-a]isoquinoline derivatives has been developed using the nickel-catalyzed reaction of 1-aryl-2-(1H-pyrazol-1-yl)ethan-1-ones and 2-bromo aldehydes. The overall transformation involves tandem Knoevenagel condensation and intramolecular direct arylation via activation of the C5−H bond of the pyrazole ring. A series of 27 drug-like aroyl−substituted pyrazolo[5,1-a]isoquinolines has been synthesized in moderate to good yields. |
URI: | https://onlinelibrary.wiley.com/doi/10.1002/adsc.201701519 http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2828 |
Appears in Collections: | Department of Chemistry |
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