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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kumar, Anil | - |
dc.contributor.author | Kumar, Dalip | - |
dc.date.accessioned | 2021-10-14T13:11:22Z | - |
dc.date.available | 2021-10-14T13:11:22Z | - |
dc.date.issued | 2018-03-05 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/10.1002/adsc.201701519 | - |
dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2828 | - |
dc.description.abstract | A simple and efficient method for the synthesis of pyrazolo[5,1-a]isoquinoline derivatives has been developed using the nickel-catalyzed reaction of 1-aryl-2-(1H-pyrazol-1-yl)ethan-1-ones and 2-bromo aldehydes. The overall transformation involves tandem Knoevenagel condensation and intramolecular direct arylation via activation of the C5−H bond of the pyrazole ring. A series of 27 drug-like aroyl−substituted pyrazolo[5,1-a]isoquinolines has been synthesized in moderate to good yields. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.subject | Chemistry | en_US |
dc.subject | Nickel-Catalyzed | en_US |
dc.subject | Synthesis of Pyrazolo | en_US |
dc.title | Nickel-Catalyzed Tandem Knoevenagel Condensation and Intramolecular Direct Arylation: Synthesis of Pyrazolo[5,1-a]-isoquinoline Derivatives | en_US |
dc.type | Article | en_US |
Appears in Collections: | Department of Chemistry |
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