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Title: | Ruthenium(II)-Catalyzed Regioselective Ortho Amidation of Imidazo Heterocycles with Isocyanates |
Authors: | Kumar, Anil Sakhuja, Rajeev |
Keywords: | Chemistry Catalysts Hydrocarbons Organic reactions |
Issue Date: | 2016 |
Publisher: | ACS |
Abstract: | Direct ortho amidation at the phenyl ring of 2-phenylimidazo heterocycles with aryl isocyanates has been achieved via a chelation-assisted cationic ruthenium(II) complex catalyzed mechanism. The methodology provides a straightforward, high-yielding regioselective approach toward the synthesis of an array of ortho-amidated phenylimidazo heterocycles without prior activation of C(sp2)–H. This also reports the first method for coupling of aryl isocyanates with the imidazo[1,2-a]pyridine system via a pentacyclometalated intermediate. The methodology is found to be easily scalable and could be applied toward the selective ortho amidation of 2-heteroarylimidazo[1,2-a]pyridine frameworks. |
URI: | https://pubs.acs.org/doi/abs/10.1021/acs.joc.6b02282 http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2841 |
Appears in Collections: | Department of Chemistry |
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