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Title: | Copper-catalyzed tandem Ullmann type C–N coupling and dehydrative cyclization: synthesis of imidazo[1,2-c]quinazolines |
Authors: | Kumar, Anil |
Keywords: | Chemistry Copper-Catalyzed Dehydrative cyclization |
Issue Date: | 2016 |
Publisher: | RSC |
Abstract: | A simple and efficient one-pot protocol has been demonstrated for the synthesis of imidazo[1,2-c]quinazoline derivatives through a copper catalyzed tandem reaction between substituted 2-(2-bromophenyl)-1H-imidazoles and formamide. The synthetic protocol involves initial Ullmann-type C–N coupling followed by intramolecular dehydrative cyclization. The method uses readily available 2-(2-bromophenyl)-1H-imidazoles as the starting materials to afford imidazo[1,2-c]quinazolines in moderate to good yields and provided 610 mg (71%) yield of 3a from a gram scale reaction. |
URI: | https://pubs.rsc.org/en/content/articlelanding/2016/ob/c5ob02469b http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2848 |
Appears in Collections: | Department of Chemistry |
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