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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kumar, Anil | - |
dc.date.accessioned | 2021-10-17T13:55:55Z | - |
dc.date.available | 2021-10-17T13:55:55Z | - |
dc.date.issued | 2015-10-19 | - |
dc.identifier.uri | https://pubs.acs.org/doi/abs/10.1021/acs.orglett.5b02539 | - |
dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2852 | - |
dc.description.abstract | The vanadium-catalyzed oxidative coupling of substituted 2-arylimidiazo[1,2-a]pyridines to N-methylmorpholine oxide, which acts as both a coupling partner and an oxidant, has been achieved. This reaction was applied to various substituted imidiazo[1,2-a]pyridine and indole substrates, resulting in yields as high as 90%. Mechanistic investigations indicate that the reaction may proceed via a Mannich-type process. This work demonstrates how oxidative aminomethylation can be used as a useful method to introduce tertiary amines into heterocycles, thus providing an alternative method for conventional Mannich-type reactions. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ACS | en_US |
dc.subject | Chemistry | en_US |
dc.subject | Catalysts | en_US |
dc.subject | Oxidative coupling | en_US |
dc.subject | Anions | en_US |
dc.subject | Byproducts | en_US |
dc.subject | Ions | en_US |
dc.title | NEXT Oxidative Cross-Coupling of sp3- and sp2-Hybridized C–H Bonds: Vanadium-Catalyzed Aminomethylation of Imidazo[1,2-a]pyridines | en_US |
dc.type | Article | en_US |
Appears in Collections: | Department of Chemistry |
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