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http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/2861| Title: | Synthesis of meso-(4′-cyanophenyl) porphyrins: efficient photocytotoxicity against A549 cancer cells and their DNA interactions |
| Authors: | Kumar, Anil Kumar, Dalip |
| Keywords: | Chemistry Meso-(4′-cyanophenyl) porphyrins Cancer cells Photocytotoxicity |
| Issue Date: | 2015 |
| Publisher: | RSC |
| Abstract: | We report a facile iodine(III)-mediated synthesis of cyanoporphyrins and their DNA photocleavage activity. Cationic-porphyrin 9a showed intercalative binding towards DNA, whereas Zn(II)-cyanoporphyrinate 9b showed outside electrostatic binding as indicated by their absorption and emission spectra. Porphyrin 9a displayed significant photocytotoxicity against A549 cancer cell line with an IC50 value of 54 nM. |
| URI: | https://pubs.rsc.org/En/content/articlelanding/2015/ra/c5ra03075g http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2861 |
| Appears in Collections: | Department of Chemistry |
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