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Title: | One-pot, three component tandem reaction of 2-aminopyridines, acetophenones and aldehydes: synthesis of 3-aroylimidazo[1,2-a]pyridines |
Authors: | Kumar, Anil |
Keywords: | Chemistry 3-aroylimidazo 2-aminopyridines |
Issue Date: | 2015 |
Publisher: | RSC |
Abstract: | A facile synthesis of 3-aroylimidazo[1,2-a]pyridine derivatives has been achieved through the one-pot, three-component tandem reaction of acetophenones, arylaldehydes and 2-aminopyridines in the presence of a catalytic amount of copper(II) chloride and air as the sole oxidant. The developed one-pot method is atom-economical and utilizes readily available precursors to offer highly functionalized N-fused imidazoles in moderate to good yields (26–82%). The presented tandem process is expected to proceed via crossed aldol condensation, Michael addition, copper catalyzed oxidative cyclization and subsequent aromatization. |
URI: | https://pubs.rsc.org/en/content/articlelanding/2015/ra/c4ra13056a http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2870 |
Appears in Collections: | Department of Chemistry |
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