![DSpace logo](/jspui/image/logo.gif)
Please use this identifier to cite or link to this item:
http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/2890
Title: | Synthesis of novel ciprofloxacin analogues and evaluation of their anti-proliferative effect on human cancer cell lines |
Authors: | Kumar, Anil |
Keywords: | Chemistry Synthesis Ciprofloxacin analogues Anti-proliferative |
Issue Date: | 2013 |
Publisher: | Elsiever |
Abstract: | A series of twenty two novel 1-cyclopropyl-6-fluoro-4-oxo-7-(4-substituted piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid analogues have been synthesized, characterized (1H NMR, 13C NMR and LCMS) and evaluated for their inhibitory activity on the proliferation of human caucasian acute lymphoblastic leukemia cells (CCRF-CEM), breast adenocarcinoma cells (MDA-MB-468) and human colon carcinoma cells (HCT-116). Among all the synthesized ciprofloxacin analogues 3t at 50 μM showed comparable potency to doxorubicin (10 μM) in all three cell lines and 3j inhibited proliferation of MDA-MB-468 up to 35% selectively over other two cell lines. |
URI: | https://www.sciencedirect.com/science/article/pii/S0960894X13011517?via%3Dihub http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2890 |
Appears in Collections: | Department of Chemistry |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.