Synthesis of novel ciprofloxacin analogues and evaluation of their anti-proliferative effect on human cancer cell lines

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DC Field	Value	Language
dc.contributor.author	Kumar, Anil	-
dc.date.accessioned	2021-10-17T13:58:46Z	-
dc.date.available	2021-10-17T13:58:46Z	-
dc.date.issued	2013	-
dc.identifier.uri	https://www.sciencedirect.com/science/article/pii/S0960894X13011517?via%3Dihub	-
dc.identifier.uri	http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2890	-
dc.description.abstract	A series of twenty two novel 1-cyclopropyl-6-fluoro-4-oxo-7-(4-substituted piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid analogues have been synthesized, characterized (1H NMR, 13C NMR and LCMS) and evaluated for their inhibitory activity on the proliferation of human caucasian acute lymphoblastic leukemia cells (CCRF-CEM), breast adenocarcinoma cells (MDA-MB-468) and human colon carcinoma cells (HCT-116). Among all the synthesized ciprofloxacin analogues 3t at 50 μM showed comparable potency to doxorubicin (10 μM) in all three cell lines and 3j inhibited proliferation of MDA-MB-468 up to 35% selectively over other two cell lines.	en_US
dc.language.iso	en	en_US
dc.publisher	Elsiever	en_US
dc.subject	Chemistry	en_US
dc.subject	Synthesis	en_US
dc.subject	Ciprofloxacin analogues	en_US
dc.subject	Anti-proliferative	en_US
dc.title	Synthesis of novel ciprofloxacin analogues and evaluation of their anti-proliferative effect on human cancer cell lines	en_US
dc.type	Article	en_US
Appears in Collections:	Department of Chemistry

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