Synthesis of Pyrazolo[3,4-d]pyrimidine Derivatives and Evaluation of their Src Kinase Inhibitory Activities

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DC Field	Value	Language
dc.contributor.author	Kumar, Anil	-
dc.date.accessioned	2021-10-17T13:59:25Z	-
dc.date.available	2021-10-17T13:59:25Z	-
dc.date.issued	2013	-
dc.identifier.uri	https://digitalcommons.chapman.edu/pharmacy_articles/89/	-
dc.identifier.uri	http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2900	-
dc.description.abstract	A series of pyrazolo[3,4-d]pyrimidine derivatives was synthesized and evaluated for the Src kinase inhibitory activities. Compound 6e and 10c exhibited inhibition of Src kinase with an IC50 value of 5.6 and 5.1 μM, respectively. Hydroxamate derivative 15a was found to be a metal-mediated inhibitor for human Csk with an IC50 value of 2.0 μM showing 56-fold selectivity over Src kinase inhibition.	en_US
dc.language.iso	en	en_US
dc.publisher	ISCB	en_US
dc.subject	Chemistry	en_US
dc.subject	Synthesis	en_US
dc.subject	Anticancer agents	en_US
dc.subject	Pyrazolo[3,4-d]pyrimidine,	en_US
dc.title	Synthesis of Pyrazolo[3,4-d]pyrimidine Derivatives and Evaluation of their Src Kinase Inhibitory Activities	en_US
dc.type	Article	en_US
Appears in Collections:	Department of Chemistry

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