Please use this identifier to cite or link to this item:
http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/2915| Title: | A Greener Synthesis of 2-Aminochromenes in Ionic Liquid and Evaluation of Their Antiproliferative Activities |
| Authors: | Kumar, Anil |
| Keywords: | Chemistry One-pot Multicomponent reaction Ionic liquid |
| Issue Date: | 2012 |
| Publisher: | ISCB |
| Abstract: | An improved simple and facile synthesis of chromene derivatives by employing three- component one-pot condensation reaction of β-naphthol, aromatic aldehydes, and malononitrile in ionic liquids is described. The ionic liquid can be reused and recycled. The chromene derivatives were evaluated for their anti-proliferative activity for human breast adenocarcinoma (MCF-7), ovarian adenocarcinoma (SK-OV-3), and acute lymphoblastic leukemia (CCRF-CEM) cell lines. Compounds 4b inhibited the cell proliferation of all three cancer cells by 60-80% at 50 μM. Among all compounds, compound 4b was the most potent against all three cancer cell lines whereas compound 4c, 4o and 4p exhibited more selectivity against CCRF-CEM. |
| URI: | https://digitalcommons.chapman.edu/pharmacy_articles/87/ http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2915 |
| Appears in Collections: | Department of Chemistry |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.