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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kumar, Anil | - |
| dc.date.accessioned | 2021-10-27T04:09:21Z | - |
| dc.date.available | 2021-10-27T04:09:21Z | - |
| dc.date.issued | 2012 | - |
| dc.identifier.uri | https://digitalcommons.chapman.edu/pharmacy_articles/87/ | - |
| dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2915 | - |
| dc.description.abstract | An improved simple and facile synthesis of chromene derivatives by employing three- component one-pot condensation reaction of β-naphthol, aromatic aldehydes, and malononitrile in ionic liquids is described. The ionic liquid can be reused and recycled. The chromene derivatives were evaluated for their anti-proliferative activity for human breast adenocarcinoma (MCF-7), ovarian adenocarcinoma (SK-OV-3), and acute lymphoblastic leukemia (CCRF-CEM) cell lines. Compounds 4b inhibited the cell proliferation of all three cancer cells by 60-80% at 50 μM. Among all compounds, compound 4b was the most potent against all three cancer cell lines whereas compound 4c, 4o and 4p exhibited more selectivity against CCRF-CEM. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | ISCB | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | One-pot | en_US |
| dc.subject | Multicomponent reaction | en_US |
| dc.subject | Ionic liquid | en_US |
| dc.title | A Greener Synthesis of 2-Aminochromenes in Ionic Liquid and Evaluation of Their Antiproliferative Activities | en_US |
| dc.type | Article | en_US |
| Appears in Collections: | Department of Chemistry | |
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