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http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/2936| Title: | Synthesis of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates and evaluation of their Src kinase inhibitory and anticancer activities |
| Authors: | Kumar, Anil |
| Keywords: | Chemistry Anticancer activity Click reaction Phenylpyrazolopyrimidine Src kinase 1,2,3-Triazole |
| Issue Date: | Mar-2011 |
| Publisher: | Elsiever |
| Abstract: | A series of two classes of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates were synthesized using click chemistry approach. All compounds were evaluated for inhibition of Src kinase and human ovarian adenocarcinoma (SK-Ov-3), breast carcinoma (MDA-MB-361), and colon adenocarcinoma (HT-29). Hexyl triazolyl-substituted 3-phenylpyrazolopyrimidine exhibited inhibition of Src kinase with an IC50 value of 5.6 μM. 4-Methoxyphenyl triazolyl-substituted 3-phenylpyrazolopyrimidine inhibited the cell proliferation of HT-29 and SK-Ov-3 by 73% and 58%, respectively, at a concentration of 50 μM. |
| URI: | https://www.sciencedirect.com/science/article/pii/S0960894X11000709?via%3Dihub http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2936 |
| Appears in Collections: | Department of Chemistry |
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