Synthesis of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates and evaluation of their Src kinase inhibitory and anticancer activities

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DC Field	Value	Language
dc.contributor.author	Kumar, Anil	-
dc.date.accessioned	2021-10-27T04:10:40Z	-
dc.date.available	2021-10-27T04:10:40Z	-
dc.date.issued	2011-03	-
dc.identifier.uri	https://www.sciencedirect.com/science/article/pii/S0960894X11000709?via%3Dihub	-
dc.identifier.uri	http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2936	-
dc.description.abstract	A series of two classes of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates were synthesized using click chemistry approach. All compounds were evaluated for inhibition of Src kinase and human ovarian adenocarcinoma (SK-Ov-3), breast carcinoma (MDA-MB-361), and colon adenocarcinoma (HT-29). Hexyl triazolyl-substituted 3-phenylpyrazolopyrimidine exhibited inhibition of Src kinase with an IC50 value of 5.6 μM. 4-Methoxyphenyl triazolyl-substituted 3-phenylpyrazolopyrimidine inhibited the cell proliferation of HT-29 and SK-Ov-3 by 73% and 58%, respectively, at a concentration of 50 μM.	en_US
dc.language.iso	en	en_US
dc.publisher	Elsiever	en_US
dc.subject	Chemistry	en_US
dc.subject	Anticancer activity	en_US
dc.subject	Click reaction	en_US
dc.subject	Phenylpyrazolopyrimidine	en_US
dc.subject	Src kinase	en_US
dc.subject	1,2,3-Triazole	en_US
dc.title	Synthesis of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates and evaluation of their Src kinase inhibitory and anticancer activities	en_US
dc.type	Article	en_US
Appears in Collections:	Department of Chemistry

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