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Title: | NMK-BH2, a novel microtubule-depolymerising bis (indolyl)-hydrazide-hydrazone, induces apoptotic and autophagic cell death in cervical cancer cells by binding to tubulin at colchicine – site |
Authors: | Kumar, Dalip |
Keywords: | Chemistry Microtubule Cervical cancer Bis (indolyl)-hydrazide-hydrazone |
Issue Date: | Oct-2020 |
Publisher: | Elsiever |
Abstract: | Microtubules, the key components of the eukaryotic cytoskeleton and mitotic spindle, are one of the most sought-after targets for cancer chemotherapy, especially due to their indispensible role in mitosis. Cervical cancer is a prevalent malignancy among women of developing countries including India. In spite of the remarkable therapeutic advancement, the non-specificity of chemotherapeutic drugs adversely affect the patients' survival and well-being, thus, necessitating the quest for novel indole-based anti-microtubule agent against cervical cancer, with high degree of potency and selectivity. |
URI: | https://www.sciencedirect.com/science/article/pii/S0167488920301208?via%3Dihub http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3016 |
Appears in Collections: | Department of Chemistry |
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