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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kumar, Dalip | - |
dc.date.accessioned | 2021-10-27T04:18:46Z | - |
dc.date.available | 2021-10-27T04:18:46Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0167488920301208?via%3Dihub | - |
dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3016 | - |
dc.description.abstract | Microtubules, the key components of the eukaryotic cytoskeleton and mitotic spindle, are one of the most sought-after targets for cancer chemotherapy, especially due to their indispensible role in mitosis. Cervical cancer is a prevalent malignancy among women of developing countries including India. In spite of the remarkable therapeutic advancement, the non-specificity of chemotherapeutic drugs adversely affect the patients' survival and well-being, thus, necessitating the quest for novel indole-based anti-microtubule agent against cervical cancer, with high degree of potency and selectivity. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsiever | en_US |
dc.subject | Chemistry | en_US |
dc.subject | Microtubule | en_US |
dc.subject | Cervical cancer | en_US |
dc.subject | Bis (indolyl)-hydrazide-hydrazone | en_US |
dc.title | NMK-BH2, a novel microtubule-depolymerising bis (indolyl)-hydrazide-hydrazone, induces apoptotic and autophagic cell death in cervical cancer cells by binding to tubulin at colchicine – site | en_US |
dc.type | Article | en_US |
Appears in Collections: | Department of Chemistry |
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