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Title: | One-pot synthesis and in-vitro anticancer evaluation of 5-(2′-indolyl)thiazoles |
Authors: | Kumar, Dalip |
Keywords: | Chemistry Anticancer Synthesis |
Issue Date: | 29-Mar-2016 |
Publisher: | Springer Nature |
Abstract: | A series of 5-(2′-indolyl)thiazoles were synthesized and evaluated for their cytotoxicity against selected human cancer cell lines. The reaction of thioamides 3 with 3-tosyloxypentane-2,4-dione 4 led to in situ formation of 5-acetylthiazole 5 which upon treatment with arylhydrazines 6 in polyphosphoric acid resulted in the formation of 5-(2′-indolyl)thiazoles 2. Among the synthesized 5-(2′-indolyl)thiazoles, compounds 2d–f and 2h exhibited encouraging anticancer activity and also selectivity towards particular cell lines (IC50 = 10–30 μM). Further studies on the SAR of compound 2e may result in good anticancer activity. |
URI: | https://www.nature.com/articles/srep23401 http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3029 |
Appears in Collections: | Department of Chemistry |
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