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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kumar, Dalip | - |
dc.date.accessioned | 2021-10-27T04:19:39Z | - |
dc.date.available | 2021-10-27T04:19:39Z | - |
dc.date.issued | 2016-12-09 | - |
dc.identifier.uri | https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.201601734 | - |
dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3030 | - |
dc.description.abstract | N-Tosylhydrazones were successfully coupled in the presence of CuI (10 mol%) with various heterocyclic amines to develop a convenient and high yielding protocol for the preparation of N-benzylaminoheterocycles under microwave irradiation. This ligand-free new methodology uses readily available starting materials and a cheaper copper catalyst. A wide range of O, N and S containing heteroarylamines and o-phenylenediamine were explored to prepare N-benzylaminoheterocycles and 1,2-disubstituted benzimidazoles. The protocol was equally effective with N-tosylhydrazones derived from aldehydes and ketones, especially ferrocene aldehyde to prepare an array of N-benzylaminoheterocycles in good to excellent yields. Finally, the identified reaction conditions were utilized to prepare drug-like molecules namely pyrido[1,2-a]benzimidazole and N-substituted-2-amino-thiazole derivative as antitubercular agents. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.subject | Chemistry | en_US |
dc.subject | Synthesis | en_US |
dc.subject | N-Benzylaminoheterocycles | en_US |
dc.subject | N-Tosylhydrazones | en_US |
dc.title | Cu–Catalyzed Expeditious Synthesis of N-Benzylaminoheter-ocycles Using N-Tosylhydrazones and Aminoheteroarenes | en_US |
dc.type | Article | en_US |
Appears in Collections: | Department of Chemistry |
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