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Title: | Synthesis of aza-fused isoquinolines through domino cross-aldol condensation and palladium-catalyzed intramolecular direct arylation |
Authors: | Kumar, Dalip Kumar, Anil |
Keywords: | Chemistry Functionalization Hydrocarbons Adducts |
Issue Date: | 2014 |
Publisher: | ACS |
Abstract: | A straightforward method has been developed for the synthesis of aroyl-substituted imidazo-/benzimidazo-fused isoquinolines. The cascade reaction proceeds via a cross-aldol condensation of 2-(1H-imidazol-1-yl/benzimidazolyl-1-yl)-1-arylethanones and 2-bromobenzaldehyde followed by palladium-catalyzed intramolecular C–H functionalization. This approach offers a simple and efficient alternative one-pot protocol for the assembly of imidazo/benzimidazo[2,1-a]isoquinolines in moderate to good yields. |
URI: | https://pubs.acs.org/doi/10.1021/jo501119f http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3037 |
Appears in Collections: | Department of Chemistry |
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