Cationic porphyrin–quinoxaline conjugate as a photochemically triggered novel cytotoxic agent

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DC Field	Value	Language
dc.contributor.author	Kumar, Dalip	-
dc.date.accessioned	2021-10-27T04:20:26Z	-
dc.date.available	2021-10-27T04:20:26Z	-
dc.date.issued	2013-06	-
dc.identifier.uri	https://www.sciencedirect.com/science/article/pii/S0960894X13004666?via%3Dihub	-
dc.identifier.uri	http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3042	-
dc.description.abstract	A novel cationic porphyrin–quinoxaline conjugate 8 was prepared in good yield by the coupling of activated quinoxaline carboxylic acid 5 with an appropriate aminoporphyrin. The UV–vis spectra of conjugate 8 with the addition of ctDNA shows substantial hypochromicity (39%) and a red shift (12 nm) in the Soret band indicating intercalation and self stacking along the surface. The binding constant of conjugate 8 with ctDNA was determined to be 1.26 × 106 M−1. The porphyrin–quinoxaline conjugate 8 displayed enhanced photocytotoxicity (IC50 = 0.06 μM) when compared to TMPyP against A549 cancer cells.	en_US
dc.language.iso	en	en_US
dc.publisher	Elsiever	en_US
dc.subject	Chemistry	en_US
dc.subject	Porphyrin conjugate	en_US
dc.subject	Quinoxaline	en_US
dc.subject	Photocytotoxicity	en_US
dc.title	Cationic porphyrin–quinoxaline conjugate as a photochemically triggered novel cytotoxic agent	en_US
dc.type	Article	en_US
Appears in Collections:	Department of Chemistry

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