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Title: | A series of 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles as potent cytotoxic agents |
Authors: | Kumar, Dalip |
Keywords: | Chemistry Potent cytotoxic 1,3,4-Thiadiazoles 2-Arylamino-1,3,4-thiadiazoles Cytotoxic agents Indolyl heterocycles |
Issue Date: | Sep-2012 |
Publisher: | EJMC |
Abstract: | A series of 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles 6a-v were prepared and studied for their anticancer activity against selected human cancer cell lines. The reaction of indolylhydrazides 3a-h with a variety of aryl isothiocyanates 4 afforded the key intermediate thiosemicarbazides 5a-v, which upon treatment with acetyl chloride produced the 2-arylamino-5-(indolyl)-1,3,4- thiadiazoles 6a-v in good yields. Most of the synthesized compounds showed selective cytotoxicity towards human breast cancer cell line (MDA-MB-231). Of the synthesized 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles, compound 6f is the most potent towards tested cancer cell lines (IC50 = 0.15-1.18 μM). |
URI: | https://experts.umn.edu/en/publications/a-series-of-2-arylamino-5-indolyl-134-thiadiazoles-as-potent-cyto http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3047 |
Appears in Collections: | Department of Chemistry |
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