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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kumar, Dalip | - |
dc.date.accessioned | 2021-10-27T04:20:38Z | - |
dc.date.available | 2021-10-27T04:20:38Z | - |
dc.date.issued | 2012-09 | - |
dc.identifier.uri | https://experts.umn.edu/en/publications/a-series-of-2-arylamino-5-indolyl-134-thiadiazoles-as-potent-cyto | - |
dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3047 | - |
dc.description.abstract | A series of 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles 6a-v were prepared and studied for their anticancer activity against selected human cancer cell lines. The reaction of indolylhydrazides 3a-h with a variety of aryl isothiocyanates 4 afforded the key intermediate thiosemicarbazides 5a-v, which upon treatment with acetyl chloride produced the 2-arylamino-5-(indolyl)-1,3,4- thiadiazoles 6a-v in good yields. Most of the synthesized compounds showed selective cytotoxicity towards human breast cancer cell line (MDA-MB-231). Of the synthesized 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles, compound 6f is the most potent towards tested cancer cell lines (IC50 = 0.15-1.18 μM). | en_US |
dc.language.iso | en | en_US |
dc.publisher | EJMC | en_US |
dc.subject | Chemistry | en_US |
dc.subject | Potent cytotoxic | en_US |
dc.subject | 1,3,4-Thiadiazoles | en_US |
dc.subject | 2-Arylamino-1,3,4-thiadiazoles | en_US |
dc.subject | Cytotoxic agents | en_US |
dc.subject | Indolyl heterocycles | en_US |
dc.title | A series of 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles as potent cytotoxic agents | en_US |
dc.type | Article | en_US |
Appears in Collections: | Department of Chemistry |
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